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Hostage Crisis at Grand Northern Bank!
What is your role? Robber, cop, negotiator, hostage, third party with a hidden agenda? Your choice!
I do have a general idea of the plot. I would like it to be very similar to Inside Man, but with a more realistic feel. This will be a literate RP and multiple paragraph writing abilities are a must
There will be at least four bank robbers and several NPCish police type figures. The hostage negotiator team might be played by me, with help from someone else. As this is a very important role.
If I see this getting quite a bit of interest I will expand everything. I want to make sure there are others interested in this idea first before doing lots more work.
Leave a post here or PM me! :)
Make the lie big, make it simple, keep saying it, and eventually they will believe it. To become a spectator of one's own life is to escape the suffering of life. <---- I totally do this. =D
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WASHINGTON ? The Obama administration is proposing new rules to help military families care for service members when they are called to active duty or become injured.
First lady Michelle Obama was set to join Labor Secretary Hilda Solis on Monday to announce the plan that updates the Family and Medical Leave Act.
The proposal would let family members take up to 12 weeks of leave from work to help a service member deployed on short notice. Family caregivers could attend military functions, deal with child care issues, or update financial affairs without fear of losing their jobs.
It would also give family members up to 26 weeks of leave to care for a service member with a serious injury or illness.
Officials also are announcing other efforts to support military families.
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DAWEI, Myanmar (Reuters) ? Myanmar opposition leader Aung San Suu Kyi called on Sunday for changes to the military-drafted constitution in her first political trip since ending a boycott of the country's political system last year and announcing plans to run for parliament.
Thousands of people lined the roads shouting "Long live mother Suu" as her motorcade moved through the rural coastal region of Dawei about 615 km (380 miles) south of her home city,
Yangon, the main business centre.
The trip, only her fourth outside Yangon since her release from years of house arrest in November 2010, demonstrates the increasingly central role of the Nobel Peace Prize laureate as the Southeast Asian state emerges from half a century of isolation.
"There are certain laws which are obstacles to the freedom of the people and we will strive to abolish these laws within the framework of the parliament," Suu Kyi said to cheers from supporters after meeting officials of her National League for Democracy (NLD) party in Dawei.
The NLD, though well known in the country, has had limited real political experience. It won by a landslide a 1990 election, a year after Suu Kyi began a lengthy period of incarceration, but the then regime ignored the result and detained many party members and supporters.
The NLD boycotted the next election, held in 2010 and won by a military-backed party after opposition complaints of rigging.
Her address on Sunday offered the most extensive detail yet of the policies she would bring to parliament.
In particular, she said she wanted to revise a 2008 army-drafted constitution that gives the military wide-ranging powers, including the ability to appoint key cabinet members, take control of the country in a state of emergency and occupy a quarter of the seats in parliament.
"We need to amend certain parts of the constitution," she said, adding the international community was poised to help Myanmar "once we are on an irreversible road to democracy."
She also said fighting between government soldiers and ethnic minority rebels had to be resolved. There has been heavy fighting recently in Kachin state but rebellions have simmered in many other regions since independence from Britain in 1948.
"Diversity is not something to be afraid of, it can be enjoyed," Suu Kyi said.
Although she has not started to campaign formally for the April 1 by-elections, the speech outside her office to supporters waving party flags and wearing T-shirts showing her face felt like a campaign stop.
"She's becoming more and more explicitly political and talking about the importance of policies," said a diplomat in the crowd. "I think it is the best speech I have heard from her."
"GREAT TRANSFORMATION"
Suu Kyi and her allies are contesting 48 seats in various legislatures including the 440-seat lower house in by-elections that could give political credibility to Myanmar and help advance the end of Western sanctions.
Business executives, mostly from Asia, have swarmed into Yangon in recent weeks to hunt for investment opportunities in the country of an estimated 60 million people, one of the last frontier markets in Asia.
Myanmar is also at the centre of a struggle for strategic influence as the United States sees a chance to expand its ties there and balance China's fast-growing economic and political sway in the region.
The visit to Dawei gives rural voters a rare glimpse of 66-year-old Suu Kyi, a symbol of defiance whose past trips outside Yangon were met with suspicion and violence by the former junta, which handed power to a nominally civilian parliament in March.
But many of the same generals who dominated the junta now lead a government on a dramatic reform drive, freeing hundreds of political prisoners, loosening media controls, calling for peace with ethnic insurgents and openly engaging with Suu Kyi and other opposition figures.
As a result, this trip was very different to one last July to Bagan, north of Yangon, where she was trailed by undercover police and kept a low profile, fearful of a repeat of an attack on her motorcade in 2003 in which 70 supporters were killed.
Suu Kyi told the World Economic Forum in Davos last week that Myanmar had not yet reached its "great transformation," but the elections in April could bring that point closer.
Many believe the turning point for Suu Kyi came on August 19, when she and President Thein Sein met in the capital, Naypyitaw. The president has since repeatedly urged parliament to pursue reforms, while Suu Kyi has voiced support for his government.
Many Burmese speculate that a senior government role, possibly even a cabinet post, awaits Suu Kyi, the daughter of assassinated independence hero General Aung San.
But to get there, much work lies ahead.
Her party has limited resources. Its headquarters are cramped and crumbling. Its senior ranks are filled with ageing activists. And there are questions over how much influence it can wield in a year-old parliament stacked with military appointees and former generals.
Her supporters, however, say her presence would bring a powerful pro-democracy voice to a chamber where many members remain reluctant to speak their mind.
"She will be able to do more inside the parliament than if she remained on the outside. There are some crucial things to do urgently concerning ethnic issues and political changes," said Ko Htin Kyaw, a dissident who was arrested in 2007 and freed in an amnesty this month.
(Additional reporting by Aung Hla Tun; Editing by Robert Birsel)
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On Christmas Eve, a massive, Chinese-made maritime oil rig, the Scarabeo 9, arrived at Trinidad and Tobago for inspection. The Spanish oil company Repsol YPF, which keeps regional headquarters in Trinidad, ferried it to the Caribbean to perform deep-ocean drilling off Cuba -- whose communist government believes as much as 20 billion barrels of crude may lie near the island's northwest coast. But it wasn't Cuban authorities who came aboard the Scarabeo 9 to give it the once-over: officials from the U.S. Coast Guard and Interior Department did, even though the rig won't be operating in U.S. waters.
On any other occasion that might have raised the ire of the Cubans, who consider Washington their imperialista enemy. But the U.S. examination of the Scarabeo 9, which Repsol agreed to and Cuba abided, was part of an unusual choreography of cooperation between the two countries. Their otherwise bitter cold-war feud (they haven't had diplomatic relations since 1961) is best known for a 50-year-long trade embargo and history's scariest nuclear standoff. Now, Cuba's commitment to offshore oil exploration -- drilling may start this weekend -- raises a specter that haunts both nations: an oil spill in the Florida Straits like the BP calamity that tarred the nearby Gulf of Mexico two years ago and left $40 billion in U.S. damages.
The Straits, an equally vital body of water that's home to some of the world's most precious coral reefs, separates Havana and Key West, Florida, by a mere 90 miles. As a result, the U.S. has tacitly loosened its embargo against Cuba to give firms like Repsol easier access to the U.S. equipment they need to help avoid or contain possible spills. "Preventing drilling off Cuba better protects our interests than preparing for [a disaster] does," U.S. Senator Bill Nelson of Florida tells TIME, noting the U.S. would prefer to stop the Cuban drilling -- but can't. "But the two are not mutually exclusive, and that's why we should aim to do both."
(MORE: Cuba Set to Begin Offshore Drilling: Is Florida In Eco-Straits?)
Cuba meanwhile has tacitly agreed to ensure that its safety measures meet U.S. standards (not that U.S. standards proved all that golden during the 2010 BP disaster) and is letting unofficial U.S. delegations in to discuss the precautions being taken by Havana and the international oil companies it is contracting. No Cuban official would discuss the matter, but Dan Whittle, senior attorney for the Environmental Defense Fund in New York, who was part of one recent delegation, says the Cubans "seem very motivated to do the right thing."
It's also the right business thing to do. Cuba's threadbare economy -- President Ra?l Castro currently has to lay off more than 500,000 state workers -- is acutely energy-dependent on allies like Venezuela, which ships the island 120,000 barrels of oil per day. So Havana is eager to drill for the major offshore reserves geologists discovered eight years ago (which the U.S. Geological Survey estimates at closer to 10 billion bbl.). Cuba has signed or is negotiating leases with Repsol and companies from eight other nations -- Norway, India, Malaysia, Vietnam, Brazil, Venezuela, Angola and China -- for 59 drilling blocks inside a 43,000-sq.-mile (112,000 sq km) zone. Eventually, the government hopes to extract half a million bpd or more.
A serious oil spill could scuttle those drilling operations -- especially since Cuba hasn't the technology, infrastructure or means, like a clean-up fund similar to the $1 billion the U.S. keeps on reserve, to confront such an emergency. And there is another big economic anxiety: Cuba's $2 billion tourism industry. "The dilemma for Cuba is that as much as they want the oil, they care as much if not more about their ocean resources," says Billy Causey, southeast regional director for the U.S. National Oceanic and Atmospheric Administration's marine sanctuary program. Cuba's pristine beaches and reefs attract sunbathers and scuba divers the world over, and a quarter of its coastal environment is set aside as protected.
So is much of coastal Florida, where tourism generates $60 billion annually -- which is why the state keeps oil rigs out of its waters. The Florida Keys lie as close as 50 miles from where Repsol is drilling; and they run roughly parallel to the 350-mile-long (560 km) Florida Reef Tract (FRT), the world's third largest barrier reef and one of its most valuable ocean eco-systems. The FRT is already under assault from global warming, ocean acidification and overfishing of symbiotic species like parrotfish that keep coral pruned of corrosive algae. If a spill were to damage the FRT, which draws $2 billion from tourism each year and supports 33,000 jobs, "it would be a catastrophic event," says David Vaughan, director of Florida's private Mote Marine Laboratory.
(MORE: Will BP Spill Lower Risk of Deepwater Drilling?)
Which means America has its own dilemma. As much as the U.S. would like to thwart Cuban petro-profits -- Cuban-American leaders like U.S. Representative and House Foreign Affairs Committee Chairwoman Ileana Ros-Lehtinen of Miami say the oil will throw a lifeline to the Castro dictatorship -- it needs to care as much if not more about its own environment. Because fewer than a tenth of the Scarabeo 9's components were made in America, Washington can't wield the embargo cudgel and fine Repsol, which has interests in the U.S., for doing business with Cuba. (Most of the other firms don't have U.S. interests.) Nor can it in good conscience use the embargo in this case to keep U.S. companies from offering spill prevention/containment hardware and services to Repsol and other drilling contractors.
One of those U.S. firms is Helix Energy Solutions in Houston. Amid the Gulf disaster, Helix engineered a "capping stack" to plug damaged blow-out preventers like the one that failed on BP's Deepwater Horizon rig. (It later contained the spill.) Having that technology at hand -- especially since the Cuba rigs will often operate in deeper waters than the Deepwater rig was mining -- will be critical if a spill occurs off Cuba.
Helix has applied to the Treasury Department for a special license to lease its equipment, and speedily deliver it, to Cuba's contractors when needed. The license is still pending, but Helix spokesman Cameron Wallace says the company is confident it will come through since Cuba won't benefit economically from the arrangement. "This is a reasonable approach," says Wallace. "We can't just say we'll figure out what to do if a spill happens. We need this kind of preparation." Eco-advocates like Whittle agree: "It's a no-brainer for the U.S."
(MORE: U.S. Fails to Respond to Cuba's Freeing of Dissidents)
Preparation includes something the U.S.-Cuba cold-war time warp rarely allows: dialogue. Nelson has introduced legislation that would require federal agencies to consult Congress on how to work with countries like Cuba on offshore drilling safety and spill response, but the Administration has already shown some flexibility. Last month U.S. officials and scientists had contact with Cuban counterparts at a regional forum on drilling hazards. That's important because they need to be in synch, for example, about how to attack a spill without exacerbating the damage to coral reefs. Scientists like Vaughan worry that chemical dispersants used to fight the spill in the Gulf, where coral wasn't as prevalent, could be lethal to reefs in the Straits. That would breed more marine catastrophe, since coral reefs, though they make up only 1% of the world's sea bottoms, account for up to 40% of natural fisheries. "They're our underwater oases," says Vaughan, whose tests so far with dispersants and FRT species like Elkhorn coral don't augur well.
A rigid U.S. reluctance to engage communist Cuba is of course only half the problem. Another is Havana's notorious, Soviet-style secrecy -- which some fear "could override the need to immediately pick up the phone," as one environmentalist confides, if and when a spill occurs. As a result, some are also petitioning Washington to fund AUVs (autonomous underwater vehicles) that marine biologists use to detect red tides, and which could also be used to sniff out oil spills in the Straits.
What experts on both sides of the Straits hope is that sea currents will carry any oil slick directly out into the Atlantic Ocean. But that's wishful thinking. So probably is the notion that U.S.-Cuba cooperation on offshore drilling can be duplicated on other fronts. Among them are the embargo, including the arguably unconstitutional ban on U.S. travel to Cuba, which has utterly failed to dislodge the Castro regime but which Washington keeps in place for fear of offending Cuban-American voters in swing-state Florida; and cases like that of Alan Gross, a U.S. aid worker imprisoned in Cuba since 2009 on what many call questionable spying charges.
U.S. inspectors this month gave the Scarabeo 9 the thumbs-up. Meanwhile, U.S. pols hope they can still dissuade foreign oil companies from operating off Cuba. Last month Nelson and Cuban-American Senator Bob Menendez of New Jersey introduced a bill to hold firms financially responsible for spills that affect the U.S. even if they originate outside U.S. waters. (It would also lift a $75 million liability cap.) Others in Congress say Big Oil should be exempted from the embargo to let the U.S. benefit from the Cuba oil find too. Either way, the only thing likely to stop the drilling now would be the discovery that there's not as much crude there as anticipated. That, or a major spill.
PHOTOS: Fidel Castro Steps Down
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DAWEI, Myanmar (Reuters) ? Myanmar opposition leader Aung San Suu Kyi called on Sunday for changes to the military-drafted constitution in her first political trip since ending a boycott of the country's political system last year and announcing plans to run for parliament.
Thousands of people lined the roads shouting "Long live mother Suu" as her motorcade moved through the rural coastal region of Dawei about 615 km (380 miles) south of her home city,
Yangon, the main business centre.
The trip, only her fourth outside Yangon since her release from years of house arrest in November 2010, demonstrates the increasingly central role of the Nobel Peace Prize laureate as the Southeast Asian state emerges from half a century of isolation.
"There are certain laws which are obstacles to the freedom of the people and we will strive to abolish these laws within the framework of the parliament," Suu Kyi said to cheers from supporters after meeting officials of her National League for Democracy (NLD) party in Dawei.
The NLD, though well known in the country, has had limited real political experience. It won by a landslide a 1990 election, a year after Suu Kyi began a lengthy period of incarceration, but the then regime ignored the result and detained many party members and supporters.
The NLD boycotted the next election, held in 2010 and won by a military-backed party after opposition complaints of rigging.
Her address on Sunday offered the most extensive detail yet of the policies she would bring to parliament.
In particular, she said she wanted to revise a 2008 army-drafted constitution that gives the military wide-ranging powers, including the ability to appoint key cabinet members, take control of the country in a state of emergency and occupy a quarter of the seats in parliament.
"We need to amend certain parts of the constitution," she said, adding the international community was poised to help Myanmar "once we are on an irreversible road to democracy."
She also said fighting between government soldiers and ethnic minority rebels had to be resolved. There has been heavy fighting recently in Kachin state but rebellions have simmered in many other regions since independence from Britain in 1948.
"Diversity is not something to be afraid of, it can be enjoyed," Suu Kyi said.
Although she has not started to campaign formally for the April 1 by-elections, the speech outside her office to supporters waving party flags and wearing T-shirts showing her face felt like a campaign stop.
"She's becoming more and more explicitly political and talking about the importance of policies," said a diplomat in the crowd. "I think it is the best speech I have heard from her."
"GREAT TRANSFORMATION"
Suu Kyi and her allies are contesting 48 seats in various legislatures including the 440-seat lower house in by-elections that could give political credibility to Myanmar and help advance the end of Western sanctions.
Business executives, mostly from Asia, have swarmed into Yangon in recent weeks to hunt for investment opportunities in the country of an estimated 60 million people, one of the last frontier markets in Asia.
Myanmar is also at the centre of a struggle for strategic influence as the United States sees a chance to expand its ties there and balance China's fast-growing economic and political sway in the region.
The visit to Dawei gives rural voters a rare glimpse of 66-year-old Suu Kyi, a symbol of defiance whose past trips outside Yangon were met with suspicion and violence by the former junta, which handed power to a nominally civilian parliament in March.
But many of the same generals who dominated the junta now lead a government on a dramatic reform drive, freeing hundreds of political prisoners, loosening media controls, calling for peace with ethnic insurgents and openly engaging with Suu Kyi and other opposition figures.
As a result, this trip was very different to one last July to Bagan, north of Yangon, where she was trailed by undercover police and kept a low profile, fearful of a repeat of an attack on her motorcade in 2003 in which 70 supporters were killed.
Suu Kyi told the World Economic Forum in Davos last week that Myanmar had not yet reached its "great transformation," but the elections in April could bring that point closer.
Many believe the turning point for Suu Kyi came on August 19, when she and President Thein Sein met in the capital, Naypyitaw. The president has since repeatedly urged parliament to pursue reforms, while Suu Kyi has voiced support for his government.
Many Burmese speculate that a senior government role, possibly even a cabinet post, awaits Suu Kyi, the daughter of assassinated independence hero General Aung San.
But to get there, much work lies ahead.
Her party has limited resources. Its headquarters are cramped and crumbling. Its senior ranks are filled with ageing activists. And there are questions over how much influence it can wield in a year-old parliament stacked with military appointees and former generals.
Her supporters, however, say her presence would bring a powerful pro-democracy voice to a chamber where many members remain reluctant to speak their mind.
"She will be able to do more inside the parliament than if she remained on the outside. There are some crucial things to do urgently concerning ethnic issues and political changes," said Ko Htin Kyaw, a dissident who was arrested in 2007 and freed in an amnesty this month.
(Additional reporting by Aung Hla Tun; Editing by Robert Birsel)
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TOKYO (Reuters) ? Japan's core consumer prices fell for the third consecutive month in the year to December, and mild deflation is expected to persist this year as energy prices stabilize and worries about Europe's debt crisis suppress wage growth and economic activity.
Core consumer prices declined an annual 0.1 percent, matching the median estimate, and a narrower measure that excludes both food and energy also fell in a sign that Japan continues to grapple with a strong yen, which pushes down import prices and makes exporters reluctant to raise salaries.
Retail sales fell 1.2 pct in 2011, the first fall in two years, and auto and machinery equipment sales posted record falls in the series, which dates back to 1980. But sales rose an annual 2.5 percent in December, the biggest increase in 16 months.
The Bank of Japan and the government concede that the economy is in a lull, and they could come under increasing pressure to support it with currency intervention and monetary policy easing as Europe's debt crisis weighs on external demand.
Europe's downturn could offset the economic benefits of rebuilding the country's earthquake-damaged northeast coast.
"The stagnation of other developed countries is likely to push back the timing of Japan beating deflation from the mid-2010s as originally thought to the late 2010s," said Takeshi Minami, chief economist at Norinchukin Research Institute.
"The BOJ will need to keep its ultra-easy stance in the meantime. If risks from the euro-zone debt crisis heighten, it could move for an additional easing in the near term."
Japan's core consumer price index (CPI) includes oil products but excludes volatile prices of fresh fruit, vegetables and seafood.
The so-called core-core inflation index, which excludes food and energy prices and is similar to the core index used in the United States, fell 1.1 percent in the year to December.
Core consumer prices in Tokyo, available a month before the nationwide data, fell 0.4 percent in the year to January. That compares with the median estimate for a 0.3 percent annual decline.
HARD TO EXPECT SELF-SUSTAINED RECOVERY SOON
Annual data showed the core CPI slipped 0.3 percent in 2011, the third straight yearly fall. Japan's consumer inflation has been around zero or minus for over a decade, except a 1.5 percent rise in 2008 on the back of an increase in energy prices.
"Overall consumption is relatively firm partly supported by reconstruction demand. But it is hard to expect to see a self-sustainable recovery in private spending," said Masamichi Adachi, senior economist at JPMorgan Securities Japan.
"With uncertainty about the economic outlook and lackluster wage growth, consumers are unlikely to boost spending."
Nippon Keidanren, the country's largest business lobby, cited this week uncertainty about energy, the strong yen and a manufacturing shift overseas as reasons why pay raises are out of the question in annual labor union negotiations in the spring.
Japan's economy will likely show a mild contraction in the fiscal year ending in March but is expected to rebound next fiscal year, supported by reconstruction demand after the March 2011 earthquake.
Reconstruction could help narrow the gap between supply and demand but won't be enough to inflate demand in excess of supply and bring about an end to deflation, economists say.
Some Bank of Japan board members see a slight delay in post-quake reconstruction demand, and the global slowdown is somewhat more acute than previously thought, minutes of the central bank's December 20-21 meeting showed on Friday.
(Additional reporting by Rie Ishiguro; Writing by Stanley White; Editing by Kim Coghill)
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Guest blogger Navy Lt. Theresa Donnelly, of U.S. Pacific Command, is the owner of Hawaii Military Pets, which provides pet resources for military families. She?s offered to share her pet-related knowledge in a series of blogs for Family Matters.
By Theresa Donnelly
Jan. 26, 2012
Although the wars are drawing down, the deployment schedules for our men and women in uniform aren?t easing up. Troops continue to meet multiple operational needs, such as theater security exercises with partner nations, Navy ship cruises and other training requirements.
Many military pet parents struggle with what to do with their forever friend when serving our nation away from home. It can be tough to stay focused on the mission at hand if family affairs aren?t in order.
Enter our partners in the nonprofit sector. For the past several years, many organizations have stepped up to the plate, providing foster pet services to our deploying troops.
?Military members have a hundred things to worry about when deployment or training comes up. The last thing they should have to worry about is the care of their pets while they?re away,? said Alisa Johnson, a Marine Corps officer and president of Dogs on Deployment, a nonprofit organization matching service members needing a foster pet family with volunteers who have agreed to take in their animals.
Alisa and her husband, Shawn, a Navy officer, observed the challenges military families face when it comes to pet care, which led to the creation of this service.
?We?re especially concerned with those military members that may live on one coast, while all their family lives on another, limiting those that they can rely on in their times of need,? Alisa said.
Since they launched the organization in June, more than 140 families have volunteered to be ?boarders? and 20 dogs have been placed in temporary foster care. ?
Along with national organizations helping troops ? including Dogs on Deployment and Guardian Angels for Soldier?s Pet ? many local animal shelters are answering the call of duty and creating programs in their communities to help deployed service members with pet care.
The Hawaiian Humane Society?s Pets of Patriots program provides pet care assistance to military personnel deploying on short notice due to war. Families living on Oahu can sign up to be foster parents, while military pet owners provide food and medical care while away from their duty station. The society assists with the written agreements, provides sample forms and helps find suitable volunteers.
Additionally, the San Diego County Humane Society offered a low-cost seminar in December for military families to provide information on pet resources for relocation and deployment.??
If you need a home for your pet while deployed, check with your local animal shelter to see if they might have a military pet outreach program, contact a national foster military pet organization or see if your command has a spouse communication network to seek temporary pet parents. The military in our own community can act as our second family, helping to provide resources for our furry friends.
This entry was posted on January 27, 2012, 10:44 am and is filed under Family Matters. You can follow any responses to this entry through RSS 2.0. You can skip to the end and leave a response. Pinging is currently not allowed.
Source: http://afps.dodlive.mil/2012/01/27/taking-care-of-pets-while-deployed/
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ScienceDaily (Jan. 26, 2012) ? A team led by researchers at the University of California, San Diego School of Medicine reports that newly discovered mutations in an evolved assembly of genes cause Joubert syndrome, a form of syndromic autism.
The findings are published in the January 26 online issue of Science Express.
Joubert syndrome is a rare, recessive brain condition characterized by malformation or underdevelopment of the cerebellum and brainstem. The disease is due specifically to alterations in cellular primary cilia -- antenna-like structures found on most cells. The consequence is a range of distinct physical and cognitive disabilities, including poor muscle control, and mental retardation. Up to 40 percent of Joubert syndrome patients meet clinical criteria for autism, as well as other neurocognitive disorders, so it is considered a syndromic form of autism.
The cause or causes of Joubert syndrome are not well-understood. Researchers looked at mutations in the TMEM216 gene, which had previously been linked to the syndrome. However, only half of the expected Joubert syndrome patients exhibit TMEM216 gene mutations; the other half did not. Using genomic sequencing, the research team, led by Joseph G. Gleeson, MD, professor of neurosciences and pediatrics at UC San Diego, broadened their inquiry and discovered a second culprit: mutations in a neighboring gene called TMEM138.
"It is extraordinarily rare for two adjacent genes to cause the same human disease," said Gleeson. "The mystery that emerged from this was whether these two adjacent, non-duplicated genes causing indistinguishable disease have functional connections at the gene or protein level."
Through evolutionary analysis, the scientists concluded that the two TMEM genes became joined end-to-end approximately 260 million years ago, about the time some amphibians began transitioning into land-based reptiles. The connected genes evolved in tandem, becoming regulated by the same transcription factors.
"Prior to this transition, the two genes had wildly different expression levels," said Jeong Ho Lee, MD, PhD, and first author of the study. "Following this transition, they became tightly co-regulated. Moreover, we found that the two encoded proteins coordinate delivery of factors key for cilia assembly."
Gleeson said the findings suggest the human genome has evolved to take advantage of fortuitous ancestral events like gene translocations to better coordinate gene expression by assembling into specific modules. When these modules are disrupted, however, neurodevelopmental diseases may result.
This research was funded, in part, by the Simons Foundation, the American Philosophical Society, the National Institutes of Health and the Howard Hughes Medical Institute.
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Source: http://www.sciencedaily.com/releases/2012/01/120126143651.htm
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The US Department of Defence have deployed 15,000 troops to the Middle Eastern state of Kuwait as tensions with Iran escalate over US and EU sanctions in response to Iran's defiance to halt its nuclear programme, which claimed to have produced its first nuclear fuel rod earlier this month. On Monday the EU passed a ban on Iranian oil exports following similar action by the US on Iran's oil and Central Bank.Iran have now threatened to blockade the Strait of Hormuz, which 35% of the World's oil shipments pass through and have been carrying out a 10 day naval exercise and missile tests. The US have stationed two nuclear powered Supercarriers in the Persian Gulf. Combined with the deployment of 15,000 troops it seems that the US is preparing for a potential conflict with Iran on all fronts. General James Mattis, who heads US Central Command got approval at the end of 2011 to station the troops in Kuwait. General Mattis believes the deployment is necessary to keep Iran in check and to ensure America is prepared for any other threats in the Middle East.
? US Navy Flickr
Despite 80% of Iran's GDP relying on oil exports Iran seem unfazed by the sanctions. "The West's ineffective sanctions against the Islamic state are not a threat to us. They are opportunities and have already brought lots of benefits to the country," Intelligence Minister Heydar Moslehi told the official IRNA news agency. With countries such as China, which relies on Iran for a third of its supply, rejecting sanctions and urging for negotiation over what Iran claims to be a peaceful nuclear research programme it seems that what happens in Iran and the Strait of Hormuz over the next couple of weeks will have a global impact.tj houshmandzadeh san onofre the little couple bubba smith bubba smith oakland strike new gmail
HARTFORD, Conn. ? The child sexual abuse scandal at Penn State University has prompted state lawmakers across the nation to take another look at laws designed to protect children and punish child predators.
Thirty-eight legislatures are back in session this month, most for the first time since retired assistant Penn State football coach Jerry Sandusky was charged in November with child sex abuse and two school officials were charged with failing to properly report abuse allegations. At least 12 states are considering mandatory reporting legislation this year, according to the National Conference of State Legislatures, and more are expected to craft bills as their sessions get into full swing.
In addition to measures to improve the reporting of suspected child sex abuse, bills have been drafted across the country that would increase or even eliminate the statutes of limitations for bringing criminal or civil cases against alleged abusers.
"The alleged incidents at Penn State I think awakened something in our national consciousness about protecting our kids," said Mike Feuer, a California assemblyman and chairman of that legislature's Judiciary Committee.
Feuer, a Los Angeles Democrat, is sponsoring a bill that would have employees at universities added to the list of mandated reporters in his state, which already includes teachers, doctors and others.
"If we were to fail to pass a bill like the one I have introduced in California only to have subsequent abuse occur, we will look back on this moment as a wasted opportunity to protect a child who will never get that moment back," he said.
Forty-eight states currently require at least some professionals to immediately report knowledge or suspicion of child sexual abuse to some authority, according to the NCSL. Eighteen of those states require every adult to be a mandated reporter.
New Jersey is another state looking to expand its mandated reporter law, and is also considering legislation that would remove a two-year time limit for bringing civil lawsuits against alleged abusers.
Assemblyman Peter J. Barnes III, D-Middlesex, the chairman of his chamber's Judiciary Committee, said he and others have been trying to get the legislation passed for years. He said now seems to be the perfect time.
"I think Penn State will be the watershed moment," he said. "Many states are going to be prompted to strengthen not only their criminal laws, but their civil laws as well, which is what we're doing."
States, including Pennsylvania, are setting up task forces or holding informational public hearings in an attempt to draft comprehensive legislative packages that might address several concerns.
Connecticut lawmakers held a hearing this week as mourners gathered at Penn State for a series of public memorial events honoring former football coach Joe Paterno, who died Sunday of lung cancer. Penn State's board of trustees fired Paterno after he was criticized over his handling of the child sex abuse allegations against Sandusky.
As the Connecticut legislature considers how to move forward, it will consider mandated reporting, setting standards for youth camps and programs at the state's public college, said state Rep. Diana Urban, co-chairwoman of the Select Committee on Children.
She said the key is making sure the proper authorities have all the information they need.
"We don't want information to go awry and to have children exposed to situations that will impact them for the rest of their lives."
Sandusky, 67, is accused of sexually abusing 10 boys over a 15-year period. He and the two school officials maintain their innocence.
Advocates for abuse victims are pushing hard for legislation to be passed this year, recognizing that the Penn State scandal presents an opportunity to cut through the government's red tape.
"It is a mobilization time. But just as important, it is a public information time," said Jim Hmurovich, chief executive of Prevent Child Abuse America. "We need to get the message out that sex offender registries and treatment services for victims and mandatory reporting requirements are important, but they're not the whole picture. Let's think about way up the river so the child never gets hurt in the first place."
Jetta Bernier agrees. A national child-abuse expert who runs Massachusetts Citizens for Children, she said the lessons learned from the recent scandal involving the Catholic church is that it doesn't help to have stiff penalties, if the warning signs of abuse are ignored or go unnoticed. She supports legislation like a bill being considered in West Virginia that would spend $1.1 million in public funds to increase child-abuse education and prevention efforts.
""It's good to begin strengthening reporting requirements, but if people don't know what to look for, the reporting just isn't going to cut it," she said. "People need to know how to identify and how to prevent. That's a piece that I have found missing in a lot of these attempts to push legislation forward."
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CARACAS, Venezuela ? Venezuela on Tuesday deported three suspected drug smugglers wanted in the United States, Canada and Colombia, touting the moves as proof the government of President Hugo Chavez is making strides in fighting trafficking.
Those deported include Luc Letourneau, a Canadian wanted in his homeland on drug trafficking charges, Oscar Martinez Hernandez, an American wanted in Puerto Rico on charges including cocaine and heroin smuggling, and Colombian Adalberto Bernal Arboleda.
Arboleda, known by his nickname "El Cali," faces drug smuggling charges in Colombia and the United States.
Justice Minister Tareck El Aissami trumpeted the deportations as evidence Venezuela is cracking down on drug trafficking.
Venezuela is a major hub for gangs that smuggle Colombian cocaine to the United States and Europe, and U.S. officials have accused Chavez's government of being lax in anti-drug efforts.
Last year, President Barack Obama's administration classified Venezuela as a country that has "failed demonstrably" to effectively fight drug trafficking.
El Aissami dismissed that accusation, accusing U.S. officials of "defaming" Venezuela's counter-drug efforts.
Letourneau, 53, was captured in May on Margarita Island, a popular tourist destination. At the time of his arrest, Letourneau was planning to smuggle 110 pounds (50 kilograms) of cocaine into Canada, El Aissami said.
Hernandez, a 44-year-old man who was nabbed by police on Jan. 4 in the western city of Maracaibo, faces numerous criminal charges ranging from drug trafficking to illegal possession of firearms and explosives.
Arboleda was captured in the town of Mariara, in central Carabobo state, on Jan. 11.
U.S.-Venezuelan counter-drug cooperation has been sharply scaled back since 2005, when Chavez suspended cooperation with the U.S. Drug Enforcement Administration and accused it of being a front for espionage.
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Every second I spent with Amy brought me that much closer to understanding a vampire?s longing for the True Death. The game is excruciating to play. The simplest act of gameplay handles like a mostly-paralyzed cave bear with narcolepsy and a chronic case of Spear Through the Eye, and occurs at speeds normally associated with bodily functions after a three-week-long grilled cheese bender.
?Shut up, hypothetical graphics boob,? I respond. ?No one says that, and Amy?s graphics look like what you?d expect to see after a prison van transporting a gang of Goth clowns collides with a tanker full of run-off from the local pig offal processing center. Now go find someone else to harangue with your nonsense.?
So yeah, don?t expect to be buoyed by some sort of redeeming feature. Every square inch of Amy is the kind of stuff that will make archeologists 1000 years in the future understand why we poured garbage into the oceans, turned dog farts into snacks for our children, and watched reality TV, before finally disappearing in a puff of acrid smoke generated by the machines that changed our diapers. In fact, they will probably conclude that Amy is responsible for the disappearance of everything from the lost colony of Roanoke, to hookers that won?t cut you with a razor blade dipped in bird-flu until after you?ve paid them. That?s right, Amy is an extinction-level event and exactly what the Mayans were trying to warn us about when they made their calendar.
Imagine going through an hour where your arms and legs responded .01 seconds later than usual. It would be completely upsetting, wouldn?t it? Humans expect things to happen at a certain speed and Amy violates those expectations in ways you?d normally have to give a credit card number to see. And it?s not helped by Amy?s nightmarish checkpoint and save system. The game only saves at the start of chapters. I cannot reiterate that enough. AMY ONLY AUTOSAVES AT THE START OF EACH CHAPTER. Don?t expect manual hard saves, either. Turn your game off, and you?ll be kicked all the way back to the start of the chapter and there?s nothing you can do about it. It is inexcusable that in 2012, a game exists that has the same attitude toward game-saves as games did twenty years ago.
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She can also cast spells by copying glyphs that appear on walls hidden around each level, but the spells are only useful during certain circumstance that are so obviously contrived as to render them pointless - another solution to a problem that only exists to justify the continued existence of the solution. They also have a certain number of uses before she needs to copy the same glyph again (and again and again and again), but don?t expect the game to tell you that, or much of anything else for that matter, anywhere. Occasionally, you?ll come across a button in another room that needs to be pushed so Amy and Lana can advance. You can tell when you come to one of those rooms because, despite all the windows, there are no doors. Instead, there is a human-sized cat door that, despite clearly being large enough for Lana to crawl through, only Amy can enter. After she has pressed the button, she won?t leave until you stand by the cat door and once again press A to activate the ?exiting the cat door? animation. Oh, and did I mention that every second she?s not standing right next to you brings you closer to death? Yeah, that happens, and most of the time to solve whatever problem is at hand requires Lana to get pretty far from Amy. Given the already super slow way Lana moves and every animation plays out, these sections are often edge-of-your-seat nail-biter moments when they don?t have to be. Other times, you?ll come across a panel for Amy to hack. This takes about 20 seconds (an eternity in Videogame Time), and you?ll have to do it every time you try to pass through such a door, even if it?s a door you?ve already hacked. Why she knows how to hack these panels is not readily explained. It has something to do with her previous treatment at a special hospital for robotic flesh puppets, but that?s all we know.
I could go on and on. I could go into detail about how the story is just reheated zombie pot pie seasoned with a creepy little girl, a pinch of religious whackadoodlery and evil science, or I could tell you that the game isn?t scary, the voice acting is bad (Marcello sounds like an alien that learned English from intercepted transmissions of Jersey Shore), the dialogue, when it?s not technobabble, is downright insipid (you might love it when Lana talks to Amy as if she?s the kind of dog owner who dresses her ?children? in sailor outfits and Amy is the dog, but I didn?t), the environmental noises create zero atmosphere, the frame rate is jittery even during the motion comic cut-scenes, and the game is headache-inducingly dark. I could also spend pages telling you about script errors and post-death level resets that can block any further progress and force you to start from the beginning of the chapter, but I won?t. I?d just be running up the score. There is simply nothing positive to say about Amy and nothing negative still worth talking about. I won?t go so far as to assume it?s one of the worst games of the year or the generation, but it?s certainly the worst game I?ve played in a long long time.
More On:AMY Companies: Lexis NumeriqueF
Do not buy Amy. Do not play Amy. Do not look at Amy. Do not think about Amy. If your sister is named Amy, move to another country, and tell people your entire family was eaten by racist wolverines.* The product in this article was sent to us by the developer/company for review.
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Source: http://www.gamingnexus.com/Article/AMY/Item3342.aspx
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Ravens quarterback Joe Flacco has just completed the fourth year of a five-year rookie contract.? He thinks he?s done enough to merit additional security.
?Definitely,? Flacco said Monday, via the team?s official website. ?We?ll see how it goes; if it goes, it goes, if it doesn?t, it doesn?t.?
So far, it hasn?t been going anywhere.? Per a source with knowledge of the situation, there have been no talks toward a new contract.
Why does Flacco think he has earned an extension?? ?I think I?m the quarterback that I am,? Flacco said.? ?I think the first four years that I?ve played here we?ve gone to the playoffs every time [and] won a game. I think the last two years that I?ve played in the playoffs, I?ve played well in the playoffs.?
I think.? I get.? The point.
But he wasn?t done.? ?And like I said earlier, I think when you watch the film and you?re a guy in this organization, I think that you can say, ?Hey, he?s played pretty damn good for us,?? Flacco added.? ?But like I said, you never know what?s going to happen.
Though owner Steve Bisciotti said last year that he envisioned negotiations beginning in 2012, there?s a chance that, once the two sides start talking, they?ll realize that there?s a significant disconnect between what the Ravens want to pay and what Flacco wants to be paid.? On one hand, Flacco?s camp surely will point to performances like the one he put together on Sunday in the AFC title game.? On the other hand, the team surely will point to his consistent pattern of inconsistency.
In the end, both sides would be wise to work something out.? While the Ravens could do a lot better at the position, they could do ? and have done ? a lot worse in the past.
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Heidi Klum is filing for divorce from Seal, according to reports.
Sources say the supermodel will file divorce papers in L.A. County Superior Court as early as next week, citing "irreconcilable differences" as the cause for the divorce.
The couple married in May 2005 and have they biological children together. Seal also adopted Heidi's eldest daughter from a prior relationship with Flavio Briatore.
So far, neither party has confirmed the report, first posted by TMZ. It is unclear what prompted the imminent dissolution of the marriage or how the matter leaked.
The pair, long regarded as one of Hollywood's most stable relationships, is famous for renewing their vows every year on their anniversary ... in a lavish ceremony.
They are also not PDA-shy when it comes to love for each other and their family. Suffice it to say, if this news is indeed true, it would be a major surprise to most.
As for splitting up their assets, there's a lot on the line.
According to Forbes, in the last year alone, Heidi Klum earned more than $20 million. It's unclear how much Seal, an award-winning recording artist, made.
[Photo: WENN.com]
Source: http://www.thehollywoodgossip.com/2012/01/report-heidi-klum-to-divorce-seal/
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Republican presidential candidate and former House Speaker Newt Gingrich prepares to walk off stage with his grand daughter Maggie Cushman, after Gingrich spoke during a?South Carolina Republican presidential primary night rally, Saturday, Jan. 21, 2012, in Columbia, S.C. Newt Gingrich won the South Carolina primary. (AP Photo/Matt Rourke)
Republican presidential candidate and former House Speaker Newt Gingrich prepares to walk off stage with his grand daughter Maggie Cushman, after Gingrich spoke during a?South Carolina Republican presidential primary night rally, Saturday, Jan. 21, 2012, in Columbia, S.C. Newt Gingrich won the South Carolina primary. (AP Photo/Matt Rourke)
Republican presidential candidate and former House Speaker Newt Gingrich speaks during a?South Carolina Republican presidential primary night rally, Saturday, Jan. 21, 2012, in Columbia, S.C. Callista Gingrich looks on at right. (AP Photo/Paul Sancya)
Former Pennsylvania Sen. Rick Santorum speaks during a South Carolina Republican presidential primary-night rally at The Citadel, Saturday, Jan. 21, 2012, in Charleston, S.C. Santorum says it's a "wide open race" for the GOP nomination, even after finishing a distant third in Saturday's primary. He'd hoped to build momentum from a late victory in the Iowa caucuses. (AP Photo/Rainier Ehrhardt)
Republican presidential candidate, former Pennsylvania Sen. Rick Santorum speaks during a South Carolina Republican presidential primary night rally at the Citadel, Saturday, Jan. 21, 2012, in Charleston, S.C. Santorum says it's a "wide open race" for the GOP nomination, even after finishing third in Saturday's primary. (AP Photo/Rainier Ehrhardt)
Republican presidential candidate, former Massachusetts Gov. Mitt Romney, stands with his wife Ann as he speaks at his South Carolina primary election night reception at the South Carolina State Fairgrounds in Columbia, S.C., Saturday, Jan. 21, 2012. Former House Speaker Newt Gingrich won the Republican primary Saturday night. (AP Photo/Charles Dharapak)
TAMPA, Fla. (AP) ? A suddenly scrambled Republican presidential contest now shifts to Florida, a day after Newt Gingrich stopped Mitt Romney's sprint to the GOP nomination by scoring a convincing victory in South Carolina.
The air of inevitability that surrounded Romney's candidacy just days ago is gone, at least for now. And his rivals, led by Gingrich, have 10 days before Florida's Jan. 31 contest to prove South Carolina was no fluke.
Florida, being much larger, more diverse, and more expensive, brings new challenges to Gingrich, who again must overcome financial and organizational disadvantages as he did Saturday.
"We don't have the kind of money at least one of the candidates has. But we do have ideas. And we do have people," Gingrich, the former House speaker, told cheering supporters Saturday night. "And we proved here in South Carolina that people power with the right ideas beats big money. And with your help, we're going to prove it again in Florida."
Romney struck a defiant tone before his own backers gathered at the South Carolina State Fairgrounds, saying: "I will compete in every single state." And wasted no time jabbing at Gingrich, saying: "Our party can't be led to victory by someone who also has never run a business and never led a state."
Former Pennsylvania Sen. Rick Santorum, having finished third in South Carolina, vowed to compete in Florida and beyond. His presence in the race ensures at least some division among Florida's tea party activists and evangelicals, a division that could ultimately help Romney help erase any questions about his candidacy by scoring a victory of his own a week from Tuesday.
Texas Rep. Ron Paul likely will not be a factor in Florida, having declared that he's bypassing the expensive state in favor of smaller subsequent contests.
As the first Southern primary, South Carolina has been a proving ground for Republican presidential hopefuls in recent years. Since Ronald Reagan in 1980, every Republican contender who won the primary has gone on to capture the party's nomination.
Returns from 95 percent of the state's precincts showed Gingrich with 41 percent of the vote to 27 percent for Romney. Santorum was winning 17 percent, Paul 13 percent.
But political momentum was the real prize with the race to pick an opponent to President Barack Obama still in its early stages.
Already, Romney and a group that supports him were on the air in Florida with a significant television ad campaign, more than $7 million combined to date.
Gingrich readily conceded that he trails in money, and even before appearing for his victory speech he tweeted supporters thanking them and appealing for a flood of donations for the Jan 31 primary. "Help me deliver the knockout punch in Florida. Join our Moneybomb and donate now," said his Internet message.
Aides to Romney, the former Massachusetts governor, had once dared hope that Florida would seal his nomination ? if South Carolina didn't first ? but that strategy appeared to vanish along with the once-formidable lead he held in pre-primary polls.
Romney swept into South Carolina 11 days ago as the favorite after being pronounced the winner of the lead-off Iowa caucuses, then cruising to victory in New Hampshire's first-in-the-nation primary.
But in the sometimes-surreal week that followed, he was stripped of his Iowa triumph ? GOP officials there now say Santorum narrowly won ? while former Utah Gov. Jon Huntsman dropped out and endorsed Romney and Texas Gov. Rick Perry quit and backed Gingrich.
Romney responded awkwardly to questions about releasing his income tax returns, and about his investments in the Cayman Islands. Gingrich, the former speaker of the House, benefited from two well-received debate performances while grappling with allegations by an ex-wife that he had once asked her for an open marriage so he could keep his mistress.
By primary eve, Romney was speculating openly about a lengthy battle for the nomination rather than the quick knockout that had seemed within his grasp only days earlier.
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Continue reading NetLED WiFi-enabled, app-controllable, LED light tubes come to Japan
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Animals differ in the amount of fat they carry around depending on their species, status and sex. However, the causes of much of this variation have been a mystery. The Bristol study shows that many differences can be understood by considering the strategies animals employ to avoid two causes of death: starvation and being killed by predators.
These causes of death often exert opposite pressures on animals, for example, storing lots of fat helps animals survive periods without food but also slows their running and so makes getting caught by a predator more likely. Animals can be stronger to compensate, but the energetic costs of extra muscle mean that the animal would starve quicker during a food shortage.
Led by Dr Andrew Higginson of Bristol's School of Biological Sciences, the researchers used mathematical models to explore how much muscle and fat animals should have in their body to give themselves the best chance of survival. They showed that an important consideration was how much carrying fat increases the energetic costs of movement. The models revealed that the size of this cost influenced whether larger animals should have more fat than smaller animals, or vice versa.
Dr Higginson said: "Our results explain differences between different families of mammal. For example, larger bats carry proportionally less fat than small bats but larger carnivores carry more fat than small carnivores. Among rodents, it's the medium-sized species that carry around the most fat! These differences agree with the models predictions if you consider the costs of carrying fat for these three groups. Bats fly and so have high costs of carrying extra weight, whilst carnivores spend much of their time resting and so will use less energy than busy scurrying rodents."
The work, published in The American Naturalist, also shows that much of the variation between animals in their amounts of fat and muscle can be explained by differences between the sexes, how much animals have to fight to get food, and the climate in which they live.
The researchers plan to put the theory to the test by looking in more detail at the amounts of fat stored by different animals. If their theory is correct, much of the mystery in how species and sexes differ in their amount of fat will have been solved.
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University of Bristol: http://www.bristol.ac.uk
Thanks to University of Bristol for this article.
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